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Literature summary for 2.5.1.141 extracted from

  • Xu, T.; Han, J.; Zhang, J.; Chen, J.; Wu, N.; Zhang, W.; Zhang, Y.
    Absence of protoheme IX farnesyltransferase CtaB causes virulence attenuation but enhances pigment production and persister survival in MRSA (2019), Front. Microbiol., 7, 1625 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.141

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Staphylococcus aureus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesyl diphosphate + protoheme IX + H2O Staphylococcus aureus
-
 diphosphate + ferroheme o
-
 ?
(2E,6E)-farnesyl diphosphate + protoheme IX + H2O Staphylococcus aureus USA500
-
 diphosphate + ferroheme o
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus USA500
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + protoheme IX + H2O
-
 Staphylococcus aureus diphosphate + ferroheme o
-
 ?
(2E,6E)-farnesyl diphosphate + protoheme IX + H2O
-
 Staphylococcus aureus USA500 diphosphate + ferroheme o
-
 ?

Synonyms

Synonyms Comment Organism
CtaB
-
 Staphylococcus aureus
protoheme IX farnesyltransferase
-
 Staphylococcus aureus

General Information

General Information Comment Organism
malfunction deletion of the enzyme gene attenuates growth and virulence in mice but enhances pigment production and formation of quinolone tolerant persister cells in stationary phase Staphylococcus aureus
physiological function the enzyme is involved in persister cell formation under stress and antibiotic treatment Staphylococcus aureus